Factor XIIIA (Cross)Links AT1 Receptors to Atherosclerosis
نویسندگان
چکیده
Angiotensin II, a small peptide hormone that plays key roles in the regulation of blood pressure, also contributes to inflammatory processes that promote the development of atherosclerosis. In this issue of Cell, AbdAlla et al. (2004) provide evidence that pathogenic actions of angiotensin II involve covalent crosslinking of angiotensin AT1 receptors by factor XIIIA transglutaminase, resulting in stable receptor dimers with enhanced signaling properties.
منابع مشابه
Factor XIIIA Transglutaminase Crosslinks AT1 Receptor Dimers of Monocytes at the Onset of Atherosclerosis
Many G protein-coupled receptors form dimers in cells. However, underlying mechanisms are barely understood. We report here that intracellular factor XIIIA transglutaminase crosslinks agonist-induced AT1 receptor homodimers via glutamine315 in the carboxyl-terminal tail of the AT1 receptor. The crosslinked dimers displayed enhanced signaling and desensitization in vitro and in vivo. Inhibition ...
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عنوان ژورنال:
- Cell
دوره 119 شماره
صفحات -
تاریخ انتشار 2004